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When compared to cyanocobalamin, methylcobalamins superior bioavailability and efficacy make it the preferred choice for many seeking to optimize their health

This medication is given as an injection into the muscle

Change You May Notice B12 Injection Oral Supplement More energy About 1 to 2 days Several weeks Mental clarity About 3 to 5 days 4 to 6 weeks Mood support About 1 to 2 weeks 1 to 2 months What Affects How Quickly a B12 Shot Works for You If you are comparing notes with a friend and wondering how fast a B12 shot works for them versus you, a few things explain the difference: Your starting levels