Li, X., J
In research settings, IGF-1 DES is widely studied for its interaction with the IGF-1 receptor (IGF-1R), a transmembrane receptor that regulates cellular growth, differentiation, metabolism, and survival signaling
Affected individuals may show other non-motor symptoms, with some being GI-oriented and emerging years before the classical motor features (Cersosimo et al., 2013)
Fukuto et al , 2004), as well as by the calmodulindependent protein kinase II homolog unc43 (Hobert, 2013)

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