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Sections were rehydrated in PBS and fixed in 4% paraformaldehyde at RT for 10 min

Continuous numeric outcomes were tested for normality and log-normality

4.2.2 Gastrointestinal and hypertensive side effects of curcumin at high doses Although curcumin is best known for its anti-inflammatory and antioxidant properties, at high concentrations it can influence COX enzymes in a way that may lead to gastrointestinal or vascular side effects

Occasionally, dose adjustment or additional peptide-based support may be recommended based on your response

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