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This multi-layered approach allowed the efficient prioritization of three candidates from large chemical libraries, supporting its applicability as a general framework for early-stage GLP-1R ligand discovery

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Emerging evidence suggests that DPP-4 inhibitor use may be associated with an increased risk of bullous pemphigoid, an autoimmune blistering disorder characterized by edematous erythema and tense blisters [13, 31]

These medications, including options like Zepbound and Oral Wegovy, operate through the GLP-1 pathway, effectively reducing appetite and aiding in substantial weight loss

Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways