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Some studies report that L-carnitine can also activate the activity of pyruvate dehydrogenase by lowering the acetyl-CoA/CoA ratio, promoting pyruvate oxidation and reducing lactate accumulation, thus improving the sustained capacity for anaerobic exercise

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These cytokines activate JAKs, which in turn phosphorylate STAT proteins, leading to their dimerization and nuclear translocation, where they initiate the transcription of pro-inflammatory genes (51)