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Nedd4 fl/fl and Aldh1l1 CreER mice (C57BL/6 background) were obtained from Cyagen Biosciences (Guangzhou, China)

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Unlike anabolic steroids that primarily increase the size of existing muscle fibers (hypertrophy), IGF-1 LR3 may also promote hyperplasia the formation of new muscle cells a potential advantage for long-term growth

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