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Aggregated peptide fragments can trigger injection site reactions that the native peptide does not cause

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Induction of Browning and Beige Adipocytes Semaglutide has been shown to promote the browning of white adipose tissue (WAT), particularly within subcutaneous depots

The label advises monitoring kidney function when starting or increasing doses in people who develop severe gastrointestinal reactions, and it notes that dehydration has been part of reported kidney injury cases