GLP-1R biased cAMP agonism maintains glycemic control with reduced malaise and emesis in preclinical mammalian models Glucagon-like peptide-1 receptor (GLP-1R) agonists improve glycemic control and promote weight loss in diabetes and obesity but are also associated with gastrointestinal adverse events, including nausea and emesis in many patients
In APP/PS1 Alzheimer's mice, Dihexa treatment not only prevented cognitive decline but actively restored spatial learning abilities that had already been compromised, indicating the compound promotes recovery of function in damaged neural circuits
An imbalance in the gut microbiome can lead to a deficiency in butyrate, which can cause metabolic stress for the colonocytes, and can even impact neurons in the brain via the gut-brain axis ( In our recent publication, we developed a hypothetical but novel argument that there are a small number of organic molecules that may be uniquely configured to support deuterium trapping on carbon atoms ( 2 in the imidazole ring is positioned between two nitrogen atoms, and it has a unique ability to exchange its proton with a deuteron in an irreversible spontaneous reaction
Van Cauter E, Leproult R, Plat L
Xin-Hui Wang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
