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These metabolomic data are consistent with our Seahorse and CyTOF analyses showing high OXPHOS, and increased expression of fatty acid oxidation and PPP enzymes in CAR T cells of LTR

For acute injuries, the traditional RICE protocol (rest, ice, compression, elevation) emphasizes immediate cold application during the first 48 hours when inflammatory processes are most active

2 Melasma is one of the skin problems that is often found

Additionally, lactic acid contributes to an acidic microenvironment, which results in cancer cell proliferation and migration via enhancing angiogenesis, and decreased cell adherence (58)