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Potential benefits for autoimmune or inflammatory conditions
This finding, in conjunction with the therapeutic effect of NaBPC157 on fully established arthritis, evidences a useful application during the entire course of adjuvant arthritis
All groups were maintained under standard laboratory conditions (12-hour light/dark cycle, temperature 22 1 C, and free access to food and water)
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The plasmid DNA encapsulated by LNPs demonstrated optimal characteristics for liver targeting, including particle size of approximately 100 nm, low polydispersity (approximately 0.2), neutral surface charges, and high DNA encapsulation efficiency (Supplementary Table 4) 25
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