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Until now, the cause of PD is unknown, but several factors seem to play a role, including environmental factors, such as the pesticide rotenone, that can block mitochondrial functions

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To further evaluate differences in metabolic adaptation, we used regression equations to predict EE from baseline body composition variables (Figure 3A and 3B) and found that SAR425899 treatment led to an equivalent metabolic adaptation for 24-hour EE (Figure 3C) but a blunting of metabolic adaptation during sleep (Figure 3D)