what was the first glp 1 Frontiers GLP-1R Agonists for Weight Loss

Protein intake often increases on GLP-1 therapy to preserve muscle during weight loss, but excessive protein without adequate fiber can worsen constipation

And that folded in some of the older GLP-1 drugs, like liraglutide, that dont work as well

Bioprocess 1, 283295

Cell culture studies using adipocytes have shown that NNMT overexpression promotes lipid accumulation and insulin resistance, while NNMT knockdown or inhibition increases NAD+ levels, activates SIRT1, enhances mitochondrial respiration, promotes expression of thermogenic genes including UCP1, and drives white adipocyte browning toward a beige phenotype

They are potent pyrogens (fever-inducers) and can cause significant non-specific inflammatory responses in many biological systems, including cell cultures