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Pure GLP-1 agonists vs dual agonists: why the distinction matters The receptor target determines the side effect profile, efficacy ceiling, and patient selection criteria

While Zepbound is not recommended during pregnancy, adequate folate intake (400-800 mcg daily) is important for women who might become pregnant

Kidney issues: Can be worsened by dehydration from vomiting/diarrhea

To ensure appropriate comparisons, only studies including an active comparator were considered, namely DPP-4i or head-to-head comparisons between GLP1-RA and SGLT2i