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Signs and Symptoms of GAD People with GAD may experience: Excessive worry on most days Trouble controlling anxious thoughts Feeling nervous, restless, or on edge Trouble focusing or concentrating Irritability or mood changes Muscle tension Headaches or stomach discomfort Feeling tired often Trouble falling asleep or staying asleep Feeling overwhelmed by small tasks Worrying even when there is little or no clear reason These symptoms can make simple daily activities feel stressful or exhausting

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J Oral Maxillofac Surg, 73, 10, pp

It activates multiple target receptor subtypes for broad systemic effects studied in preclinical models

Common cellular and molecular mechanisms and interactions between microglial activation and aberrant neuroplasticity in depression