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doi: 10.1002/dmrr.2873 52 ParkCW

Shukla R

Enhanced Antioxidant Protection By neutralizing free radicals, glutathione protects cells from damage that can contribute to chronic diseases

The combination of GPX4 inhibitors with immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis increases the proportion of CD8 + T cells, enhances their cytotoxic activity and induces ferroptosis, thereby promoting chemotherapy resistance [42]

The use of DXN to induce chemobrain in rats is highly relevant to clinical comorbid conditions, as it replicates the increased oxidative stress observed in such scenarios (Chiang et al., 2023)