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HNSCC is majorly a cancer of adults with a median age of diagnosis of 66 years for HPV negative and 53 years for HPV positive HNSCC

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CBDQ has been shown to form protein adducts with key targets (e.g., TOP2A and KEAP1 47,113 ), but further work is needed to map adduct formation across other proteins, cysteine residues, and cell types beyond airway epithelium

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This domain organization is characterized by establishment of a ring-like structure termed the desensitization ring, first postulated for the agonist-bound GluK2 homomer structure (Meyerson et al., 2016)