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These should jointly assess SIRT1 activity, NRF2-related redox pathways, oxidative stress and cytokine panels, and SCFAs and other microbiota-derived metabolites alongside clinical outcomes, ideally within multi-omic frameworks of the dietmicrobiotametabolome axis

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The authors noted that delayed gastric emptying and reduced thirst may require more active treatment with bulk-forming laxatives like psyllium, stool softeners such as docusate sodium, or osmotic or stimulant laxatives like polyethylene glycol

Finally, intermittent (flash) or continuous glucose monitoring technology, usually used in the management of diabetes mellitus, can also be helpful in RH management

Caution is required when prescribing phentermine and it is not recommended for patients with a history of CVD, hypertension, or a history of cardiac arrhythmias or seizures