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Tirzepatide is a new class of medication that can offer eligible people living with obesity another treatment option and potentially reduce the economic impact of obesity, which is estimated to cost the NHS 6.1 billion annually. This authorisation is based on results from the phase 3 SURMOUNT-1 and SURMOUNT-2 clinical trials, which both met their co-primary endpoints of demonstrating that tirzepatide 10mg and 15mg achieved superior mean percent change in body weight from baseline and greater percentage of participants achieving body weight reductions of at least 5% compared to placebo

Localization of senescent cell antigen on band 3

doi: 10.1900/RDS.2011.8.369

Gastric motility and the gut-brain axis Slowed gastric emptying is a direct peripheral effect of GLP-1 receptor activation on the vagus nerve and enteric nervous system

The difference was not significant for NFMI ( 2 2.22, df 1, p 0.14) or NFS ( 2 1.78, df 1, p 0.18)