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The GLP1R gene variant rs6923761 influences receptor density and signaling efficiency, meaning some people achieve appetite suppression with lower doses and frequencies, while others need more frequent dosing for equivalent results

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Semaglutide is a medication primarily used for managing type 2 diabetes and, more recently, for weight loss in adults

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Both medications work by mimicking natural hormones that control hunger and metabolism, but there is a slight difference in their engines. The Bottom Line: Retatrutide offers a modest increase in potential weight loss (approximately 3%), but it is still in clinical trials