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By engaging all three pathways at once, it offers researchers a tool for studying multi-receptor metabolic signalling in ways that single-agonist compounds cannot

Am J Physiol Cell Physiol 281:C1964C1970 Romera C, Hurtado O, Botella SH, Lizasoain I, Cardenas A, Fernandez-Tome P, Leza JC, Lorenzo P, Moro MA (2004) In vitro ischemic tolerance involves upregulation of glutamate transport partly mediated by the TACE/ADAM17-tumor necrosis factor-alpha pathway

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This pathway is a major source of NADPH, and in addition to its importance in red blood cells, it provides about half the NADPH required for fatty acid synthesis