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The crystal structure of the wild-type AR illustrated the reason why the LxxLL motifs of typical NR coactivators fail to hydrogen bond with Glu897 of H12 and make fewer and less optimized hydrophobic contacts with the AF2 pocket compared with FxxLF-containing peptides, explaining the lower affinity of AF2 for the LXXLL-containing p160-type coactivators 82

Wu C, Zhu M, Lu Z, Zhang Y, Li L, Li N, Yin L, Wang H, Song W, Xu H (2021) L-carnitine ameliorates the muscle wasting of cancer cachexia through the AKT/FOXO3a/MaFbx axis

Avoid or reduce the intake of caffeine, soft drinks and alcohol that inhibit nutrient absorption

D-Carnitine: This form is toxic to the body as it can hinder the absorption of other carnitine forms, thereby causing a carnitine deficiency