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Although tachyphylaxis to this effect may occur with long-acting GLP-1 receptor agonists, GLP-1-related slowing of gastric emptying does not appear to be responsible for the nausea and vomiting often reported with the use of GLP-1 receptor agonist treatment

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Although it has been established that NO decreases the flow of electrons through the respiratory chain complexes, which inhibits respiration and decreases oxygen consumption (Giulivi et al., 2006), the physiological impact of this effect has yet to be fully elucidated

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