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Most weight loss research has focused on naltrexone combined with bupropion (a different antidepressant), which is FDA-approved as Contrave

Moiz and colleagues found that retatrutide 12 mg weekly (Eli Lilly) showed the greatest effect on obesity among all agents in the review, producing weight loss of up to 22.1% (95% CI, 19.3%-24.9%) after 48 weeks of treatment

According to the National Institutes of Health, the FDA has not approved BPC-157 because of concerns about its safety in humans