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Further research focus on genetic screening for at-risk individuals, exploring microbiome-based interventions, and developing pharmacological strategies that optimize bilirubin metabolism

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These should jointly assess SIRT1 activity, NRF2-related redox pathways, oxidative stress and cytokine panels, and SCFAs and other microbiota-derived metabolites alongside clinical outcomes, ideally within multi-omic frameworks of the dietmicrobiotametabolome axis

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