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Cardiovascular effects: Transient changes in blood pressure and heart rate may occur during administration

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Phosphoflow B cells were fixed and permeabilized using the Cytofix/Perm buffer III (BD Biosciences) or the Foxp3/Transcription factor staining buffer (Invitrogen) in accordance with the manufacturers protocol

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One clinical trial found that zinc supplementation, combined with standard treatment, helped reduce withdrawal severity and cravings