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Lanosterol has been found to inhibit transmembrane protein 175 (TMEM175), a lysosomal proton export channel, and its clearance via CYP51A1-dependent metabolism restores TMEM175 function, thereby dampening lysosomal alkalinization and mitigating the induction of alkaliptosis [68]

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The biochemical characterization allowed identifying not less than 442 variants of the deficiency of the enzyme

Lin TK, Lin KJ, Lin HY, Lin KL, Lan MY, Wang PW, Wang TJ, Wang FS, Tsai PC, Liou CW, Chuang JH (2021) Glucagon-like Peptide-1 receptor agonist ameliorates 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) neurotoxicity through enhancing mitophagy flux and reducing -Synuclein and oxidative stress