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Because safety hasn't been established, the standard advice is to skip it while pregnant or nursing unless a doctor says otherwise (WebMD)

While no major safety flags have emerged from either the scientific literature or widespread anecdotal use, the absence of large-scale human data means users should proceed carefullyespecially if considering high doses or long-term use

The MHRA can step in if a supplement is marketed as treating a disease or modifying a body function in a way that crosses into medicinal territory

A study involving the cortex of juvenile and adult Fmr1- KO mice has revealed impaired mitochondrial energy metabolism

They might do perfectly fine on a fraction of the standard dosing schedules for years, keeping their metabolic markers in check without aggressive intervention