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82 While the Warburg effectcharacterized by increased aerobic glycolysisis a metabolic hallmark observed across many tumor types, CSCs exploit this and other metabolic programs in a highly plastic manner to support their survival and proliferative advantage under stress

Another key epigenetic mechanism that controls gene transcription involves chromatin remodeling mediated by the SWI/SNF complex, which has been revealed to be related to SLC7A11 transcriptional regulation (Ogiwara et al., 2019)

Agents that target immune modulation and have anti-viral and endothelium-protective effects may present exciting targets for pharmacological intervention of LC patients

AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE-/- mice

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