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Other entero-pancreatic hormones and combination of entero-pancreatic hormones in the management of obesity Numerous entero-pancreatic hormones [GIP, glucagon, amylin and peptide YY (PYY) agonists and GIP antagonists] with diverse metabolic actions are currently under investigation either alone or in combination with GLP-1 RA (Fig

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But based on clinical observation, research, and anti-inflammatory effects, Tirzepatide remains the best option for Lipedema patients as it has the dual effects of GLP-1 and GIP

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