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Roughly 10% of the population carries these variants, which appear to cause a mysterious form of "GLP-1 resistance." In several clinical trials, carriers were significantly less likely to reach healthy blood sugar targets while taking GLP-1 medications

Prx1 Cys83 binds to cullin-3, a ubiquitin ligase modulating Nrf2 ubiquitination [150] , and thereby inhibits degradation of Nrf2 allowing transcription of anti-ferroptotic enzymes [149]

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