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Allopurinol is the first-line ULT, typically started at 100mg daily and titrated to achieve target serum uric acid levels below 360 mol/L (or below 300 mol/L in people with tophi)

You may also notice reduced bloating after carb-heavy meals

Furthermore, AZ Dyrk1B 33 improves glucose control in larval and juvenile zebrafish and diabetic mice

In addition to the studies demonstrating the central effects of GLP-1 and its analogs on satiety and reduction of energy intake, there are studies showing other central effects of GLP-1 involving BAT

Important safety considerations include reduced exposure to oral contraceptives (requiring use of a barrier method for 4 weeks after initiation and each dose escalation) and avoidance during pregnancy and breastfeeding