Counting by molecule type: 17 are peptides, 4 are small molecules (HM-15275, SP-2297, CS-120070, RAY-0221), 2 are Fc-fusion proteins (MWN-101, ZX2021), 1 is an ADC (IBI-3012), and 2 are listed as "chemical drugs" without more specificity (DYX116, XFL6)
These receptors primarily couple to Gs proteins that stimulate adenylate cyclase, increasing intracellular cyclic AMP concentrations
The medications can help with weight loss because they make you feel fuller faster
Contraindications:: Patients with a personal or family history of medullary thyroid carcinoma (based upon animal data - see FDA Warning) History of hypersensitivity to semaglutide or any of its excipients (serious reactions including angioedema & anaphylaxis have been reported) Side Effects: GI Adverse events: nausea, vomiting, constipation, diarrhea (~5-15%) most GI side side effects occur during dose initiation or escalation and wane after a few weeks (Drucker, 2024)
Canadian adult obesity clinical practice guidelines: medical nutrition therapy in obesity management
