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22 The carbon monoxide in cigarette smoke reversibly binds various heme-containing proteins within the body

Gastrointestinal effects Nausea is the most common side effect, affecting roughly 41% of participants in the REDEFINE 1 trial

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Some guidelines recommend holding GLP-1 receptor agonists before procedures requiring sedation or general anesthesia to reduce the risk of aspiration, though specific recommendations may vary based on the procedure type and individual patient factors