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Laboratory investigations using ionizing radiation-induced senescent cells demonstrate that FOXO4-DRI causes p53 nuclear exclusion and mitochondrial targeting, validating the proposed mechanism of selective senescent cell elimination through targeted protein-protein interaction disruption

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Jalan R, Wright G, Davies NA, Hodges SJ

Clinical studies confirm that chronic treatment with AOD9604 showed no adverse effect on insulin sensitivity, making it a metabolically selective approach to body composition optimization under medical supervision

Angelucci, O