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Abstract Cytokines such as tumor necrosis factor (TNF) are expressed at high levels in rheumatoid joint tissue, where they contribute significantly to inflammation and articular destruction

Therefore, as expected we found increased mRNA expression of Gsr and other NRF2-regulated genes ( Gclm , Nqo1 , Srxn1 and Hmox1 ) (Fig 2A), as well as NRF2 and GSR protein abundance (Fig 2B) in LPS-stimulated RAW264.7 Ms with accumulated oxLDL

It is a self-sustaining system consisting of small molecules such as vitamins E and C, glutathione 59,60 , and antioxidative defense enzymes, such as superoxide dismutase 61 , catalase 62,63 , glutathione peroxidase, glutathione reductase, and glutathioneS-transferases 62

doi: 10.1093/oxfordjournals.humrep.a019263 162 FernandezJLMurielLRiveroMTGoyanesVVazquezRAlvarezJG