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In kidney and heart, indeed, lipid peroxidation and oxidative damage preceded necrosis (Repetto et al., 2010b)

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The peptide functions as a retrograde signal from mitochondria to the nucleus, communicating mitochondrial status and coordinating adaptive responses to metabolic stress

As expected, ultraviolet B was highly melanomagenic but, in contrast to the previous data for albino mice, ultraviolet A treatment of pigmented animals also initiated melanoma (Fig