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Nevertheless, although the classical Arg1/iNOS competition model provides an important framework for understanding the involvement of arginine metabolism in macrophage polarization, its applicability in the complex pathological environment in vivo still requires cautious consideration

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Exogenously administered GSH protects against oxidative damage in cultured human RPE 17 , while GSH depletion was shown to cause cell death 18

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Enomoto et al., 2002)