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Notably, LEICA required lower AG1 concentrations than in vitro and cell-based screens 15 , probably due to differences in reaction constituents concentrations (for example, substrates, cofactors and enzymes) or compound bioavailability across bacterial and mammalian membranes

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[DOI] [PubMed] [Google Scholar] 38.Coghill D.R., Caballero B., Sorooshian S., Civil R