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Conversely, in cellular contexts dependent upon Parkin-mediated mitophagy for survival, interference with this pathway via MST1-p53 axis activation or FFAR2/PPAR- signaling blockade enhances cellular susceptibility to ferroptosis upon Erastin treatment

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Since the patient was an extreme athlete, this finding with its respective recommendation, may have prevented a potentially fatal episode of sudden cardiac death

Positive results from a pilot study [86] prompted a phase 2 trial of UDCA in PD, which confirmed its safety, tolerability, target engagement measured via 31-phosphorus magnetic resonance spectroscopy (31P-MRS), and reported gait improvement in the objective sensor-based analysis