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NICE Technology Appraisal 875 recommends semaglutide 2.4 mg (Wegovy) as an option for weight management in adults with a BMI of at least 35 kg/m (or 32.5 kg/m in certain ethnic groups) and at least one weight-related comorbidity

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However, the comparison of NNT across various drug classes must be nuanced given the NNT values are specific to individual trial design, study population baseline characteristics, and the time of outcome measurement

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