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A 2014 study found that only 0.22% of the applied dose had penetrated the stratum corneum after 24 hours

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Haj M, Wijeweera A, Rudnizky S, Taunton J, Pnueli L, Melamed P

This pulsatile activity was also observed in mutant animals, defective in neurotransmitter and neuropeptide secretion, suggesting that these sensory neurons may implement such intricate computation in a cellautonomous manner