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Fiorentino TV, Casiraghi F, Davalli AM, et al (2019) Exenatide regulates pancreatic islet integrity and insulin sensitivity in the nonhuman primate baboon Papio hamadryas

Semaglutide mimics the action of the naturally occurring hormone GLP-1, which regulates appetite and food intake

We should note here that the preservation of weight loss and food intake inhibition by GIPR antagonism in mice with disturbed GIPR signalling in the PNS is not unexpected, given that mice with CNS loss of Gipr (thus, mimicking the use of an antagonist) show decreased body weight and food intake when fed a HFD 15 , suggesting that the reduction in body weight by GIPR antagonism is mediated by neurons of the central rather than peripheral nervous system

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