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These tissues are considered to be the last to decrease their thiamine content during TD and the first to replete it upon thiamine administration, with the liver serving as the thiamine depot for other tissues (156)

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TNF- promotes Tumor Necrosis Factor Receptor 1 (TNFR1)-mediated internalization of GABA receptors, upregulates -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor expression, and enhances synaptic excitability, thereby triggering seizures and exacerbating emotional and cognitive dysfunction (Tripathi et al., 2024)

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Better insulin sensitivity may improve glucose control

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For Indian skin (Fitzpatrick IVVI) Ascorbic acid has been shown to support barrier function and may help address post-inflammatory hyperpigmentation (PIH), a significant concern in Fitzpatrick IV-VI skin types prevalent in Kerala

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