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First isolated in 1973 by Loren Pickart from human albumin fractions, this naturally occurring peptide found in blood plasma has since become one of the most investigated copper peptides in preclinical research, with findings that suggest broad implications for skin remodeling, inflammation reduction, and even central nervous system function

However, substantial heterogeneity among studies was observed, likely attributable to differences in dosage, baseline B12 status, and population characteristics

Effectively blocking the transcription of pro-inflammatory cytokines like TNF-, IL-1, and IL-6

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