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In particular, 4IgB7-H3 is restricted to glioblastoma cells and may serve as a target for therapy, while 2IgB7-H3 presents with higher expression in recurrent glioblastoma and increases resistance to temozolomide (122)
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Native IGF-1 has a plasma half-life of approximately 10-20 minutes because it binds insulin-like growth factor binding proteins (IGFBPs), particularly IGFBP-3, which clears it rapidly
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