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Previously we showed that RAP guanine exchange factors EPAC1/2 (Exchange Proteins Activated by cyclic AMP) promote the growth of primary melanoma and loss of dependency on EPACs is associated with metastatic progression

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Goldstein DS, Jinsmaa Y, Sullivan P, et al

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The biologic significance of these data needs further examination, but these findings support our prior statements on the importance of immune cell phenotyping and the role of peripheral dopamine biomarkers in defining the mechanisms and/or prognosis of neuropsychiatric/neurodevelopmental disorders