This ongoing inflammatory fire drives many of the debilitating, systemic symptoms patients experience months or even years after the initial acute infection has seemingly cleared
Physiol Rev 59:527605 Ng CF, Schafer FQ, Buettner GR, Rodgers VG (2007) The rate of cellular hydrogen peroxide removal shows dependency on GSH: mathematical insight into in vivo H2O2 and GPx concentrations
Additionally, via phosphorylating SLC7A11 at serine 26, mTORC2 reduces the functioning of the SLC7A11 transporter (105)
The subsequent pathophysiologic mechanisms can be summarized as acute tubular apoptosis, oxidative stress, inflammation, microcirculatory dysfunction, vascular barrier function disorder, local hypoxia, and tissue edema (84)
Compared to genetic techniques, small molecules are convenient to use, concentration-dependent, rapidly reversible, and spatially controlled