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CAD: carbamoyl-phosphate synthetase 2 aspartate transcarbamylase, and dihydroorotase

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This increase is observed in several diseases including congenital deficits in urea cycle enzymes, Reyes syndrome in children, uraemic encephalopathy, diabetic encephalopathy, or hypoglycaemic encephalopathy, although the most frequent cause for hyperammonaemia is associated with acute (due to poisons or drugs) and chronic (cirrhosis) liver failure

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