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In case a patient develops pancreatitis, discontinue semaglutide immediately

DPP-4 Inhibitors Mechanism of action Competitive inhibition of dipeptidyl-peptidase 4 slows degradation of endogenous incretins (GLP-1, GIP) Glucose-dependent insulin secretion Post-prandial glucagon release No direct effect on weight or insulin sensitivity Glycaemic efficacy Advantages Weight-neutral useful when metformin + SU cause weight concern Low hypoglycaemia risk (incretin-dependent action) Oral, generally once-daily

Gastrointestinal Side Effects in IBD: Separating Medication from Disease Flare GLP-1 side effectsnausea, vomiting, constipation, and abdominal painoverlap with Crohn's symptoms

Kalina M, Mason RJ, Shannon JM

Choosing the best form of magnesium supplements can be tricky due to the many different types (magnesium aspartate, bicarbonate, carbonate, chloride, citrate and others)