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Unanswered Questions Regarding Weight Loss Mechanisms: Perspectives to Preclinical Research The exact mechanisms underlying the weight loss are still not clear, especially in light of the enhanced effects seen with multi-agonism, despite the large number of incretin agonists presently undergoing clinical trials and their remarkable effectiveness in managing obesity and T2DM [5, 14, 146, 147]

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This slow progression is critical to allow the intestinal flora to adapt to the presence of undigested carbohydrates, thereby reducing gastrointestinal side effects

Researchers isolated and stabilised this fragment to study how the organism shields and repairs itself, and since the late 1990s the Zagreb group led by Sikiri and colleagues has built much of the foundational literature around it (Sikiri et al., 2024)